Relationships among fecal daidzein metabolites, dietary habit and BMI in healthy volunteers: a preliminary study

Motoi TAMURA; Sachiko HORI; Hiroyuki NAKAGAWA; Kazuhiro KATADA; Kazuhiro KAMADA; Kazuhiko UCHIYAMA; Osamu HANDA; Tomohisa TAKAGI; Yuji NAITO; Toshikazu YOSHIKAWA

doi:10.12938/bmfh.2014-019

This article has now been updated. Please use the final version.

Relationships among fecal daidzein metabolites, dietary habit and BMI in healthy volunteers: a preliminary study

Motoi TAMURA, Sachiko HORI, Hiroyuki NAKAGAWA, Kazuhiro KATADA, Kazuhiro KAMADA, Kazuhiko UCHIYAMA, Osamu HANDA, Tomohisa TAKAGI, Yuji NAITO, Toshikazu YOSHIKAWA

Author information

Motoi TAMURA
National Food Research Institute of the National Agriculture and Food Research Organization Tsukuba, Japan
Sachiko HORI
National Food Research Institute of the National Agriculture and Food Research Organization Tsukuba, Japan
Hiroyuki NAKAGAWA
National Food Research Institute of the National Agriculture and Food Research Organization Tsukuba, Japan
Kazuhiro KATADA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Kazuhiro KAMADA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Kazuhiko UCHIYAMA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Osamu HANDA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Tomohisa TAKAGI
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Yuji NAITO
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan
Toshikazu YOSHIKAWA
Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Japan

Keywords: daidzein, dihydrodaidzein, equol, microbiota

JOURNAL FREE ACCESS Advance online publication

Article ID: 2014-019

DOI https://doi.org/10.12938/bmfh.2014-019

The final version of this article is now available: Vol. 34 (2015), No. 3 pp. 59-65

Details

Abstract

To investigate the relationships among fecal isoflavone metabolism, dietary habit and Body Mass Index (BMI), 15 healthy men and 15 healthy women were recruited and provided stool samples for analysis of ex vivo anaerobic incubation of fecal suspension with daidzein. A negative correlation was observed between BMI and the dihydrodaidzein (DHD) production in men, and between BMI and the equol production in women. There was a positive correlation between intake of soluble dietary fiber and the DHD production in men. The results suggest that dietary habits and BMI are related to the metabolic activity of isoflavonoids by fecal intestinal microbiota.

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