Biological and Pharmaceutical Bulletin
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Cancer Chemopreventive Activity of Odorine and Odorinol from Aglaia odorata
Akira INADAHoyoku NISHINOMasashi KUCHIDEJunko TAKAYASUTeruo MUKAINAKAYoshitaka NOBUKUNIMasato OKUDAHarukuni TOKUDA
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2001 Volume 24 Issue 11 Pages 1282-1285

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Abstract

In the course of our continuing search for novel cancer chemo-preventive agents from natural sources, we have carried out a primary screening in vitro assay of the compounds isolated from Aglaia odorata. Consequently, aminopyrrolidine-diamides, odorine and odorinol, were obtained as active constituents. These compounds exhibited potent anti-carcinogenic effects in a two-stage carcinogenesis test of mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Further, both compounds showed remarkable inhibitory effects in two-stage mouse skin carcinogenesis models induced by nitric oxide (NO) donors such as (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide (NOR-1) or peroxynitrite as an initiator and TPA as a promoter. From these results, it was concluded that odorine and odorinol inhibited both the initiation and promotion stages of two-stage skin carcinogenesis.

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© 2001 The Pharmaceutical Society of Japan
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