Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Antiproliferative Sesquiterpene Lactones from the Roots of Inula helenium
Tenji KonishiYasuo ShimadaTsuneatsu NagaoHikaru OkabeTakao Konoshima
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2002 Volume 25 Issue 10 Pages 1370-1372

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Abstract

The MeOH extract of the roots of Inula helenium showed a high inhibitory activity for cell growth against MK-1, HeLa and B16F10 cell lines. Significant activity was found in the hexane-soluble fraction. From the hexane-soluble fraction, seven sesquiterpenes, namely, one germacrane (4β,5α-epoxy-1(10),11(13)-germacradiene-8,12-olide), one elemane (igalane), and five eudesmanes (alantolactone, isoalantolactone, 11α,13-dihydro-alantolactone, 11α,13-dihydro-isoalantolactone, 5-epoxyalantolactone) were isolated. In vitro antiproliferative activities of the isolates against MK-1, HeLa and B16F10 cells are reported.

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© 2002 The Pharmaceutical Society of Japan
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