Biological and Pharmaceutical Bulletin
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Ursolic Acid as a Trypanocidal Constituent in Rosemary
Fumiko AbeTatsuo YamauchiTsuneatsu NagaoJunei KinjoHikaru OkabeHiroo HigoHiroshige Akahane
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Volume 25 (2002) Issue 11 Pages 1485-1487

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Abstract

The MeOH extract of the leaves of rosemary (Rosmarinus officinalis L.) completely inhibited the motility of cultured epimastigotes of Trypanosoma cruzi at the concentration of 2 mg/ml after 2 h of incubation. Activity-guided fractionation of the MeOH extract has resulted in the isolation of three triterpene acids, betulinic, oleanolic and ursolic acids. Ursolic acid stopped the movement of all T. cruzi epimastigotes at the minimum concentration (MC100) of 40 μg/ml (88 μM) after 48 h of incubation. Oleanolic acid was less active (MC100: 250 μg/ml, 550 μM) and betulinic acid was practically inactive.

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© 2002 The Pharmaceutical Society of Japan
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