Antipruritic Effect of Cnidii Monnieri Fructus (Fruits of Cnidium monnieri Cusson)

Hideaki Matsuda; Yasuko Ido; Atsushi Hirata; Yoshiaki Ino; Shunsuke Naruto; Tsutomu Amamiya; Michinori Kubo

doi:10.1248/bpb.25.260

Notes

Antipruritic Effect of Cnidii Monnieri Fructus (Fruits of Cnidium monnieri Cusson)

Hideaki Matsuda, Yasuko Ido, Atsushi Hirata, Yoshiaki Ino, Shunsuke Naruto, Tsutomu Amamiya, Michinori Kubo

著者情報

キーワード: Cnidium monnieri, antipruritic effect, isopimpinellin, osthol

ジャーナルフリー

2002 年 25 巻 2 号 p. 260-263

DOI https://doi.org/10.1248/bpb.25.260

詳細

抄録

Antipruritic effects of 70% ethanol extract (CM-ext) of Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri Cusson, Umberifferae) were investigated. In mice, an oral administration of CM-ext (200 and 500 mg/kg) inhibited compound 48/80-induced scratching behavior without influence on spontaneous locomotion. Isopimpinellin (3) and osthol (1), coumarin derivatives isolated from CM-ext, showed an inhibitory effect on compound 48/80-induced scratching behavior.

責任著者(Corresponding author)

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