Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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65件中1~20件の論文を表示しています
  • 43 巻 (2020) 7 号 p. 1061-1066
    Evidence of Passive Smoking as a Risk Factor of High-Grade Squamous Intraepithelial Lesion: A Case-Control Study もっと読む
    編集者のコメント

    The association between risk factors and occurrence or development of cervical intraepithelial lesions, such as persistent infection with high-risk human papillomavirus (HPV), multiple sexual partners and smoking have been discussed. However, the effect of passive smoking on the disease is unclear. In this case-control study, Du et al. found that passive smoking was a significant independent risk factor on the occurrence of HSIL and showed a positive correlated dose-response relationship. HPV infection interacting with passive smoking led to an even higher disease risk. Adolescent exposure to passive smoking persistent for more than 20 years would also increase the HSIL risk.

  • 43 巻 (2020) 7 号 p. 1104-1110
    Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts もっと読む
    編集者のコメント

    Aging is the most important risk factor for various diseases such as cancer, osteoarthritis, dementia, atherosclerosis, and infection. Therefore, the researchers has attempted to find phytochemicals for ameliorating aging-related diseased. Latifolin, isolated from Dalbergia odorifera T. Chen, has been reported to exhibit anti-inflammatory and anti-carcinogenic activities. In present study, the authors investigated the anti-aging effect of latifolin in human dermal fibroblasts. Modulation of SIRT1 may be involved in latifolin protective effect against H2O2-induced oxidant injury. These results suggest that latifolin supplementation might be a possible route for improving aging and age-related diseases.

  • 43 巻 (2020) 7 号 p. 1111-1117
    Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus もっと読む
    編集者のコメント

    Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition, an appropriate mouse model should be developed. Andoh et al. established a surgically-induced mouse model of cholestatic pruritus and evaluated anti-pruritic effects of several drugs using this mouse model. In results, they suggested that partial obstruction of bile secretion in mice induced anti-histamine-resistant itching and that central opioid system is involved in cholestatic itching.

  • 43 巻 (2020) 7 号 p. 1118-1122
    Single Molecule Fluorescence Imaging Reveals the Stoichiometry of BKγ1 Subunit in Living HEK293 Cell Expression System もっと読む
    編集者のコメント

    Large conductance Ca2+-activated K+ (BKCa) channels possess significant physiological functions in various types of cells. The stoichiometry between BKa and newly identified ɤ1 subunits (BKɤ1) remains unclear. Here, the authors utilized a single molecule fluorescence imaging with a total internal reflection fluorescence (TIRF) microscope to directly count the number of GFP-tagged BKɤ1 within a single BKCa channel complex in HEK293 expression system. Counting of GFP bleaching steps revealed that a BKCa channel contains mainly four BKɤ1 per channel. These results suggest that BKɤ1 forms a BKCa channel complex with BKa in a 1:1 stoichiometry in a human cell line.

  • 43 巻 (2020) 6 号 p. 932-937
    Ziyuglycoside II Inhibits Rotavirus Induced Diarrhea Possibly via TLR4/NF-κB Pathways もっと読む
    編集者のコメント

    In the present study, Ziyuglycoside II inhibits rotavirus (RV) induced diarrhea via toll-like receptor 4 (TLR4)/nuclear factor kappa-B (NF-κB) signaling pathway. Ziyuglycoside II inhibited the proliferation of MA104 cells infected with RV via suppressing RV duplication. The combination of Ziyuglycoside II and Ribavirin protected against RV-induced diarrhea through regulating TLR4/NF-κB signaling pathway. Moreover, the combined treatment suppressed the level of pro-inflammation cytokines and overexpressed anti-inflammation cytokine. Moreover, the combined therapy improved the lesion changes and inhibited the cell apoptosis in vivo. Thus Ziyuglycoside II may function as protective role in RV-induced diarrhea.

  • 43 巻 (2020) 6 号 p. 959-967
    Characterization and Immunological Activities of Polysaccharides from Polygonatum sibiricum もっと読む
    編集者のコメント

    Polygonatum sibiricum first appeared in ancient Chinese medicine books around 1000 years ago and is used to tonify the spleen and nourish the lungs. The authors present here a kind of natural polysaccharides (PSP) extracted from Polygonatum sibiricum were purified, characterized and assayed both in vitro and in vivo for its immunomodulatory activity and mechanism. It is of interest to note that PSP not only regulated the immune function of normal mice, but participated in the protection against immunosuppression in cyclophosphamide-treated mice, highlighting its potential as an immunostimulant.

  • 43 巻 (2020) 6 号 p. 968-975
    Potential Mechanisms Underlying the Hepatic–Protective Effects of Danshensu on Iron Overload Mice もっと読む
    編集者のコメント

    Danshensu (3-(3,4-dihydroxyphenyl)-(2R)-lactic acid) is one of the water-soluble active ingredients of Salvia miltiorrhizae, a traditional Chinese medicine for the treatment of cardiovascular diseases. This study investigated the protective effects of Danshensu on the acute liver injury induced by iron overload in mice. The results indicated that the underlying mechanisms at least partly involve anti-oxidation, anti-inflammation, anti-apoptosis, and decreasing hepatic iron deposition possibly through down-regulating the expression of iron uptake related proteins, such as DMT1, TfR, and L-type Ca2+ CP α1C. Therefore, they conclude Danshensu could be a promising prophylactic or therapeutic agent for iron overload diseases.

  • 43 巻 (2020) 6 号 p. 1007-1015
    Detection of Abacavir-Induced Structural Alterations in Human Leukocyte Antigen-B*57 : 01 Using Phage Display もっと読む
    編集者のコメント

    The interaction of human leukocyte antigen (HLA) with specific drugs induces structural alteration in HLA and delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Shirayanagi et al. selected specific phage antibodies able to recognize HLA-B*57:01 and evaluated structural alterations in HLA-B*57:01 complexes induced by abacavir. The affinity of selected phage antibodies increased because of structural alterations in HLA-B*57:01 following exposure to abacavir, indicating that specific phage antibodies can identify drug-mediated structural changes in HLA complexes. These results suggest that phage display technology is a useful method for detecting structural changes in HLA complexes.

  • 43 巻 (2020) 5 号 p. 823-830
    Predicting Method for the Human Plasma Concentration–Time Profile of a Monoclonal Antibody from the Half-life of Non-human Primates もっと読む
    編集者のコメント

    Efficiency and animal welfare are important factors in the development of new drugs. Considering this, Nakamura et al. propose a new way of predicting human PK for mAbs that is more efficient than conventional methods. By collecting mAb PK data on linear elimination and analyzing a two-compartment model, they revealed that half-life during elimination is the main contributor to plasma clearance. Based on this feature, they developed a novel method that uses easy-to-obtain parameters from humans and non-human primates to predict human PK. Called the half-life method, it can improve animal welfare and potentially accelerate the drug development process.

  • 43 巻 (2020) 5 号 p. 839-847
    Ethenzamide Exerts Analgesic Effect at the Spinal Cord via Multiple Mechanisms of Action Including the 5HT2B Receptor Blockade in the Rat Formalin Test もっと読む
    編集者のコメント

    Ethenzamide (ETZ) is widely used as an OTC pain reliever, however, its site of action and mechanism underlying its analgesic action had not yet been fully elucidated. The article by Nikaido et al. provides evidence suggesting that the analgesic effect of ETZ in the rat formalin test was mediated by multiple mechanisms of action including the 5-hydroxytryptamine2B receptor blockade at the spinal cord.

  • 43 巻 (2020) 5 号 p. 859-863
    Abnormal Vascular Phenotypes Associated with the Timing of Interruption of Retinal Vascular Development in Rats もっと読む
    編集者のコメント

    Pathological angiogenesis is a leading cause of blindness in several retinal diseases. Kondo et al. demonstrated that only a 2-day treatment of neonatal rats with the VEGF receptor tyrosine kinase inhibitor at different time points could induce abnormal blood vessels with different vascular pathological features (intravitreal neovascularization vs. tortuous arteries) in the retina. Pharmacological agents targeting the VEGF signaling pathway are useful for creating an abnormal retinal vasculature with various pathological features in order to study the mechanisms underlying abnormal retinal angiogenesis and evaluate the efficacy of anti-angiogenic compounds.

  • 43 巻 (2020) 5 号 p. 873-878
    Cancer Cachexia May Hinder Pain Control When Using Fentanyl Patch もっと読む
    編集者のコメント

    The transdermal fentanyl patch (FP) has been used worldwide to relieve cancer pain. However, no previous studies have examined the influence of cancer cachexia on pain control in cancer patients receiving FP treatment. Chiba et al. found that cancer cachexia may be a risk factor for poor pain control in patients receiving FP treatment, and that uncontrolled pain in FP treatment may be caused by the inhibition of fentanyl transdermal absorption due to dry skin.

  • 43 巻 (2020) 5 号 p. 898-903
    Fluorinated Kavalactone Inhibited RANKL-Induced Osteoclast Differentiation of RAW264 Cells もっと読む
    編集者のコメント

    To discover small molecules that affect osteoclastogenesis, Kumagai et al designed and synthesized styrylpyrone analogs, and discovered (E)-6-(2-fluorostyryl)-4-methoxy-2H-pyran-2-one (22) has osteoclast-inhibitory activities in murine RAW264 cells. A partial structure-activity relationship revealed that fluorine and its position within the styrylpyrone skeleton were important. Authors also revealed that compound 22 prevents osteoclastic bone resorption by inhibiting osteoclastogenesis. Compound 22 downregulated mRNA expression levels of RANKL-induced nuclear factor of activated T cells c1 (NFATc1) and osteoclastogenesis-related genes. These findings may be useful for the desigh of antiresorptive agents for the treatment of bone disorders characterized by excessive osteoclastic activity .

  • 43 巻 (2020) 4 号 p. 575
    Foreword もっと読む
    編集者のコメント

    The 34th Annual Meeting of the Academy of Pharmaceutical Sciences and Technologies, Japan (APSTJ) was held in Toyama, Japan, May 16–18, 2019. In this meeting, a joint symposium was held with the Pharmaceutical Society of Japan and APSTJ. The theme of the symposium was “Recent Advances in Research on Particulate Formulations such as Lipoproteins, Liposomes, Extracellular Vesicles, and iPS Derived Cells.” The four invited speakers provide their review articles in the Current Topics of this issue.

  • 43 巻 (2020) 4 号 p. 682-687
    Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients もっと読む
    編集者のコメント

    Interactions between drugs and pharmaceutical additives can cause problems when mixing multiple drugs in clinical settings. One example is aggregate formation between levofloxacin hydrate tablets and lansoprazole orally disintegrating tablets. Nakagawa et al investigated the factors involved in this aggregation, focusing on the role of pharmaceutical additives and electrostatic interaction. Levofloxacin, which is zwitterionic, formed aggregates with methacrylic acid copolymer LD, one of the pharmaceutical additives of lansoprazole orally disintegrating tablet. Other zwitterionic ingredients, including ampicillin, meropenem, cefepime, and cephalexin, also formed aggregates with methacrylic acid copolymer LD.

  • 43 巻 (2020) 4 号 p. 688-692
    In Vitro Inhibitory Effects of Sesamin on CYP4F2 Activity もっと読む
    編集者のコメント

    Sesamin is a major lignan in sesame seeds, and a recent meta-analysis of controlled trials showed that sesamin consumption reduces blood pressure. The antihypertensive effect of sesamin was suggested to be caused by suppression of cytochrome P450 4F2 (CYP4F2)-mediated 20-hydroxyeicosatetraenoic acid production. However, the detailed mechanism underlying inhibition of CYP4F2 function by sesamin was unclear. The article by Watanabe et al. characterized the in vitro inhibitory effects of sesamin on human CYP4F2 activity. The results indicated that sesamin is a mechanism-based inactivator of CYP4F2.

  • 43 巻 (2020) 4 号 p. 697-706
    Transport Characteristics of 5-Aminosalicylic Acid Derivatives Conjugated with Amino Acids via Human H+-Coupled Oligopeptide Transporter PEPT1 もっと読む
    編集者のコメント

    5-Aminosalicylic acid (5-ASA) is used as first line therapy for inflammatory bowel disease (IBD). However, a very high 5-ASA dose is required for IBD treatment because 5-ASA formula is relatively low delivery efficacy to local inflamed colonic sites. In this report, Yuri et al. focused on an intestinal H+-coupled oligopeptide transporter 1 (PEPT1) which is induced in the colon under IBD condition, and demonstrated that the newly synthesized dipeptide-like 5-ASA derivatives, which are coupling glycine, glutamic acid and valine to amino group of 5-ASA, were transportable substrates for PEPT1.

  • 43 巻 (2020) 3 号 p. 361
    Foreword もっと読む
    編集者のコメント

    Cutting-edge contributions from invited poster presentations providing significant research works in the fifth International Symposium for Medicinal Sciences (ISMS) in the 139th Chiba annual meeting in 2019 are assembled for the Current Topics section in this issue of the Biological and Pharmaceutical Bulletin.

  • 43 巻 (2020) 3 号 p. 450-457
    Resveratrol Attenuates Inflammatory Bowel Disease in Mice by Regulating SUMO1 もっと読む
    編集者のコメント

    Mao et al. found that resveratrol can significantly inhibit the expression of SUMO1. They demonstrate that resveratrol alleviates inflammatory bowel disease (IBD) in mice by inhibiting the expression of SUMO1 molecule, and by modulating the activation of wnt/β-catenin signaling pathway. Clinical analysis also proves that the expression of SUMO1 and β-catenin molecules increased with the worsening of the disease, which also provides a new method for clinical diagnosis and treatment of IBD.

  • 43 巻 (2020) 3 号 p. 458-462
    Risk Factors for Major Bleeding and Clinically Relevant Non-major Bleeding in Japanese Patients Treated with Edoxaban もっと読む
    編集者のコメント

    Edoxaban is an oral anticoagulant used for preventing and treating stroke or systemic embolism. Bleeding is the most common complication associated with anticoagulants. In particular, severe bleeding is assumed to be related to mortality in patients treated with anticoagulation therapy. However, few studies have examined the risk factors for bleeding in Japanese patients receiving edoxaban. The article by Takase et al. revealed that a low baseline hemoglobin level was a significant risk factor for major and clinically relevant bleeding in Japanese patients receiving edoxaban.

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