Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Nobiletin as a Tyrosinase Inhibitor from the Peel of Citrus Fruit
Kenroh SasakiFumihiko Yoshizaki
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2002 Volume 25 Issue 6 Pages 806-808

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Abstract

A tyrosinase inhibitor was isolated from the peel of Citrus fruit by activity-guided fractionation, and identified as 3′,4′,5,6,7,8-hexamethoxyflavone (nobiletin) by comparison with reported spectral data. Nobiletin (IC50 of; 46.2 μM) exhibited more potency than Kojic acid (IC50; 77.4 μM) used as a positive control, and it was found to be potentially an effective inhibitor of the production of melanin.

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© 2002 The Pharmaceutical Society of Japan
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