Pharmacological Evaluation of Shokyo and Kankyo (1)

Kazunori Hashimoto; Yoshio Kase; Pin Murata; Toshitaka Kido; Yoichiro Nakai; Iwao Sakakibara; Masami Higuchi; Hiroshi Sasaki; Minoru Okada

doi:10.1248/bpb.25.1183

Regular Articles

Pharmacological Evaluation of Shokyo and Kankyo (1)

Kazunori Hashimoto, Yoshio Kase, Pin Murata, Toshitaka Kido, Yoichiro Nakai, Iwao Sakakibara, Masami Higuchi, Hiroshi Sasaki, Minoru Okada

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Kazunori Hashimoto
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Yoshio Kase
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Pin Murata
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Toshitaka Kido
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Yoichiro Nakai
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Iwao Sakakibara
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Masami Higuchi
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Hiroshi Sasaki
Kampo & Pharmacognosy Laboratory, Tsumura & Co.
Minoru Okada
Kampo & Pharmacognosy Laboratory, Tsumura & Co.

Keywords: Zingiber officinale, gastric emptying, intestinal blood flow, Zingiberis Rhizoma, Zingiberis Siccatum Rhizoma, shogasulfonic acid A

JOURNAL FREE ACCESS

2002 Volume 25 Issue 9 Pages 1183-1187

DOI https://doi.org/10.1248/bpb.25.1183

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Abstract

Zingiberis Rhizoma (Shokyo) showed significant ameliorative effect on the BaCl₂-induced delay of gastric emptying in rat. Bioassay-guided fractionation of the aqueous extract of Shokyo resulted in isolation of 6-gingesulfonic acid (1) and shogasulfonic acid A (3). These compounds significantly improved the delay of gastric emptying on both BaCl₂-induced and N^G-nitro-L-arginine (L-NNA)-induced model in rat.

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