A Possible Mechanism for the Exchange of Transferrin–⁶⁷Ga Complex to Heparan Sulfate–⁶⁷Ga Complex

Abstract

We attempted to identify the exchange mechanism of transferrin–⁶⁷Ga complex to heparan sulfate–⁶⁷Ga complex. The effect of phosphate on the binding ability of ⁶⁷Ga to transferrin and heparan sulfate was studied by the dialysis method. The phosphate inhibited the binding ability of ⁶⁷Ga to transferrin, while the phosphate enhanced the ⁶⁷Ga binding ability to heparan sulfate. The results suggest that the phosphate is involved in the translocation of ⁶⁷Ga from the transferrin to the heparan sulfate.