Hypotensive Activity and Toxicology of Constituents from Bombax ceiba Stem Bark

抄録

A novel constituent, shamimicin, 1′′′, 1′′′′′′′-bis-2-(3,4-dihydroxyphenyl)-3,4-dihydro-3,7-dihydroxy-5-O-xylopyranosyloxy-2H-1-benzopyran alongwith lupeol, which possesses potent hypotensive activity has been isolated from Bombax ceiba stem bark. BCBMM—one of the most active hypotensive fractions has revealed its adverse effects on heart, liver and kidneys of mice at the dose of 1000 mg/kg/d.