Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Effect of 2,5-Dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats
Kenji YamadaMiwa SanoHisato FujiharaAkihiro Ohta
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2003 Volume 26 Issue 11 Pages 1614-1617

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Abstract

Effect of 2,5-dimethylpyrazine (2,5-DMP) on oxytocic agent-induced late pregnant uterine contraction in female rats was studied. Oxytocic agents induced-hypercontraction in the late phase of pregnant uterine movements were inhibited by administration of 2,5-DMP. The inhibition of uterine contraction was obtained more strengthening by presence of a low dose of ritodrine hydrochloride than 2,5-DMP alone. These results suggests that 2,5-DMP has an inhibitory action on uterine hypercontraction induced by oxytocic agent through the β2-adrenoceptor in the pregnant uterus and supports the appllicability of relaxing drugs for oxytocic agent-induced accidents.

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© 2003 The Pharmaceutical Society of Japan
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