Effect of Dried Fruits of Solanum nigrum L<small>INN</small> against CCl4-Induced Hepatic Damage in Rats

Kuppuswamy Raju; Govindaraju Anbuganapathi; Velusamy Gokulakrishnan; Balasubramanian Rajkapoor; Balasundarm Jayakar; Sellamuthu Manian

doi:10.1248/bpb.26.1618

Notes

Effect of Dried Fruits of Solanum nigrum LINN against CCl₄-Induced Hepatic Damage in Rats

Kuppuswamy Raju, Govindaraju Anbuganapathi, Velusamy Gokulakrishnan, Balasubramanian Rajkapoor, Balasundarm Jayakar, Sellamuthu Manian

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Keywords: Solanum nigrum, carbon tetrachloride (CCl₄), hepatoprotective activity

JOURNAL FREE ACCESS

2003 Volume 26 Issue 11 Pages 1618-1619

DOI https://doi.org/10.1248/bpb.26.1618

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Abstract

Ethanol extract of Solanum nigrum LINN was investigated for its hepatoprotective activity against CCl₄-induced hepatic damage in rats. The ethanol extract showed remarkable hepatoprotective activity. The activity was evaluated using biochemical parameters such as serum aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP) and total bilirubin. The histopathological changes of liver sample in treated animals were compared with respect to control.

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