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Biological and Pharmaceutical Bulletin
Vol. 26 (2003) No. 5 P 736-738

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http://doi.org/10.1248/bpb.26.736

Notes

The anti-lipid peroxidation (LP) activity and anti-superoxide formation (SOD) of new N-H and N-substituted indole derivatives were evaluated to determine their antioxidant activity. The results showed that compounds 1, 2, 5, 9 and 12 demonstrate considerable inhibition of lipid peroxidation of mouse liver homogenate. On the other hand, compounds 5 and 12 showed anti-superoxide formation activity at a concentration of 10−4 M. Consequently, it can be concluded that these compounds exhibit important activity compared with reference compound α-tocopherol (vitamin E).

Copyright © 2003 The Pharmaceutical Society of Japan

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