Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Inhibition of Intracerebroventricular Injection Stress-Induced Plasma Corticosterone Levels by Intracerebroventricularly Administered Compound K, a Ginseng Saponin Metabolite, in Mice
Do-Hoon KimJun-Sub JungYoo-Sun MoonJong-Hwan SungHong-Won SuhYung-Hi KimDong-Keun Song
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2003 Volume 26 Issue 7 Pages 1035-1038

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Abstract

Effects of major intestinal metabolites of ginsenosides, including compound K (IH-901, 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol), compound Y (IH-902, 20-O-[α-L-arabinopyranosyl (1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol), and ginsenoside Mc (IH-903, 20-O-[α-L-arabinofuranosyl (1→6)-β-D-glucopyranosyl]-20(S)-protopanaxadiol), on acute stress-induced plasma corticosterone levels were studied in mice. Intracerebroventricularly (i.c.v.) administered compound K (1 μg) attenuated the i.c.v. injection stress-induced increase in plasma corticosterone level, and this inhibitory effect was not affected by co-administered NG-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor. Compound K administered intraperitoneally affected neither the i.c.v. injection stress- nor the immobilization stress-induced increase in plasma corticosterone levels. Compound K and ginsenoside Mc did not affect plasma corticosterone levels induced by the two stress modalities used in this study.

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© 2003 The Pharmaceutical Society of Japan
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