Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Melanin Biosynthesis Inhibitors from the Bark of Machilus thunbergii
Gao Li, Hye Kyung Ju, Hyuen Wook Chang, Yurngdong Jahng, Seung-Ho Lee, Jong-Keun Son
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Keywords: Machilus thunbergii, Lauraceae, bark, lignan, melanin biosynthesis inhibitor
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2003 Volume 26 Issue 7 Pages 1039-1041

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Abstract
The bioassay-guided fractionation of the methylene chloride soluble portion of a methanol extract of Machilus thunbergii bark led to the isolation of four known lignans, machilin A (1), meso-monomethyl dihydroguaiaretic acid (2), nectandrin A (3) and nectandrin B (4), which exhibited potent inhibitory activity on melanin biosynthesis in cultured B-16 mouse melanoma cells (IC50: 39.9, 15.1, 19.4 and 37.8 μM, respectively).
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© 2003 The Pharmaceutical Society of Japan
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