Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Communications to the Editor
Cell Growth Inhibitory Effect of Cinnamic Acid Derivatives from Propolis on Human Tumor Cell Lines
Yukihiro AkaoHiroe MaruyamaKenji MatsumotoKenji OhguchiKumi NishizawaTakashi SakamotoYoko ArakiSatoshi MishimaYoshinori Nozawa
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2003 Volume 26 Issue 7 Pages 1057-1059


A cell growth inhibitory effect of drupanin and baccharin, ingredients of propolis, was found in human cancer cell lines. These compounds induced apoptosis in the cells characterized by morphological and nucleosomal DNA fragmentation analysis. Their effects were less potent compared with that of artepillin C, which is a known anticancer compound from propolis. Importantly, HL60 cells were more sensitive to drupanin than were Con A-stimulated peripheral blood lymphocytes, whereas the potency of artepillin C was the opposite of that of drupanin.

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© 2003 The Pharmaceutical Society of Japan
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