Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Phosphoproteome Analysis of Hereditary Cataractous Rat Lens α-Crystallin
Akira KameiShinsuke TakamuraMakoto NagaiNoriko Takeuchi
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2004 Volume 27 Issue 12 Pages 1923-1931

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Abstract

We reported previously that C-terminal truncated α-crystallins were found in lenses of hereditary cataractous rat ICR/f. In this study, we examined the phosphorylation of the crystalline lens proteins, αB-crystallin and αA-crystallin, in cataractous and normal rats of different ages and have found an increase in the phosphorylation of serine residues of truncated α-crystallin in cataractous lens. Phosphorylation and C-terminal truncation of α-crystallins could, both, reduce their chaperone-like activity and lead to cataract formation.

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© 2004 The Pharmaceutical Society of Japan
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