Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
Ying-Jun ZhangTsuneatsu NagaoTakashi TanakaChong-Ren YangHikaru OkabeIsao Kouno
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JOURNALS FREE ACCESS

2004 Volume 27 Issue 2 Pages 251-255

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Abstract

Eighteen main compounds, including four norsesquiterpenoids (1—4) and 14 phenolic compounds (5—18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5—8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.

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© 2004 The Pharmaceutical Society of Japan
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