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Biological and Pharmaceutical Bulletin
Vol. 27 (2004) No. 3 P 404-406



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When hot-water extracts of mushroom Agaricus brazei MURRILL fruiting bodies (Agaricus extracts) were administered orally into Meth A-bearing mice, tumor growth was significantly inhibited compared with controls given water orally. Treatment with Agaricus extracts for five successive days significantly increased natural killer activity of spleen cells in naïve BALB/c mice. In Meth A-bearing BALB/c mice, Agaricus extracts enhanced the induction of antigen-specific cytotoxic T lymphocytes and interferon γ production, indicating that Agaricus extracts potentiate cytotoxic activity in innate and adaptive immunity.

Copyright © 2004 The Pharmaceutical Society of Japan

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