Abstract
The aim of the present study was to determine the antimicrobial and cytotoxic activities of eight novel titanium(III) based coordination complexes [Ti(Pht)2(DL-serine)2, S1], [Ti(Pht)2(glycine)2, S2)], [Ti(Pht)2(cystine)2, S3], [Ti(Pht)2(DL-leucine)2, S4], [Ti(Suc)2(L-leucine)2, S5], [Ti(Suc)2(cystine)2, S6], [Ti(Suc)2(cystein)2, S7] and [Ti(Suc)2(DL-serine)2, S8] against several gram-positive and -negative bacteria, fungi and brine shrimp nauplii. The investigation showed that almost all of the complexes were moderately active against tested bacteria and fungi at high concentration (200 μg/disc) compared with the standard antibiotic, amoxicillin and the antifungal agent, nystatin. In vivo lethality bioassay experiment showed that only S7 and S8 among the complexes had better cytotoxic effect than standard gallic acid. The LC50 values of these two complexes were found to be 1.00 and 1.21 μg/ml, respectively. Thus the results suggest that only two complexes (S7, S8) among the titanium(III) based coordination complexes show the anticancer properties comparable to the standard cytotoxic agent, and further studies of these two complexes may be helpful for their clinical implication.
