Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats
Toshinobu SekiHiroshi KanbayashiTomonobu NagaoSumio ChonoMikio TomitaMasahiro HayashiYasuhiko TabataKazuhiro Morimoto
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2005 年 28 巻 3 号 p. 510-514

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Absorption enhancers, which increase the permeability of drugs through epithelial membranes without damaging them, are especially useful for intranasal administration of peptide drugs. In this study, aminated gelatins, candidate enhancers, having different numbers of amino groups were prepared from gelatin (H-gelatin, isoelectric point=9.0, MW 100 kDa) and a partial gelatin hydrolysate (L-gelatin, isoelectric point=8.0, MW 5 kDa), and the enhancing effects on the nasal absorption of insulin, used as a model peptide drug, and 5(6)-carboxyfluorescein (CF), a paracellular marker, were examined in rats. The enhancing effect on insulin and CF depends on the MW and number of amino groups. A high correlation between the enhancing effects on insulin and CF was observed and this suggests that an increase in the paracellular permeability is the mechanism governing the nasal absorption-enhancement of aminated gelatins, at least as far as insulin and CF are concerned. The enhancing mechanism might be shared with other cationic polymers having absorption-enhancing effects.

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© 2005 The Pharmaceutical Society of Japan
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