Enhancement of All-trans Retinoic Acid-Induced HL-60 Cell Differentiation by Thalidomide and Its Metabolites

Tomomi Noguchi; Chihiro Shinji; Hisayoshi Kobayashi; Makoto Makishima; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/bpb.28.563

Communications to the Editor

Enhancement of All-trans Retinoic Acid-Induced HL-60 Cell Differentiation by Thalidomide and Its Metabolites

Tomomi Noguchi, Chihiro Shinji, Hisayoshi Kobayashi, Makoto Makishima, Hiroyuki Miyachi, Yuichi Hashimoto

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Keywords: thalidomide, hydroxythalidomide, retinoic acid, differentiation, tubulin

JOURNAL FREE ACCESS

2005 Volume 28 Issue 3 Pages 563-564

DOI https://doi.org/10.1248/bpb.28.563

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Abstract

Thalidomide (Thal: 1) and its two metabolites, 5-hydroxythalidomide (5-HT: 2) and N-hydroxythalidomide (N-HT: 3), showed an enhancing effect on all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation. 5-HT and N-HT showed tubulin polymerization-inhibiting activity, but thalidomide did not.

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