A Glycosidic Isoflavonoid from Viola hondoensis W. BECKER et H. BOISSIEU (Violaceae), and Its Effect on the Expression of Matrix Metalloproteinase-1 Caused by Ultraviolet Irradiation in Cultured Human Skin Fibroblasts

Abstract

Isolation of the ethyl acetate soluble fraction from aerial parts of Viola hondoensis W. BECKER et H. BOISSIEU yielded one major isoflavonoid glycoside, tectoridin-4′-O-β-D-glucoside. The structure of the compound was certainly determined by chemical analyses, as well as 1D- and 2D-NMR spectroscopy. The compound exhibited potent inhibitory activity against the expression of matrix metalloproteinase-1 caused by UV-irradiation in cultured human skin fibroblasts.