Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8
Toru HosoiYasunobu OkumaAtsushi OnoYasuyuki Nomura
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2005 Volume 28 Issue 8 Pages 1514-1516

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Abstract
We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14—18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.
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© 2005 The Pharmaceutical Society of Japan
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