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Biological and Pharmaceutical Bulletin
Vol. 28 (2005) No. 8 P 1514-1516

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http://doi.org/10.1248/bpb.28.1514

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Alteration of Leptin-Induced STAT3 Activation in the Brain of Senescence-Accelerated Mouse (SAM) P8

Toru Hosoi1) 3), Yasunobu Okuma1) 4), Atsushi Ono1), Yasuyuki Nomura1) 2)

1) Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University 2) Daiichi University, College of Pharmaceutical Sciences 3) Department of Pharmacotherapy, Graduate School of Biomedical Sciences, Hiroshima University 4) Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science

Released 2005/08/01  
received 2005/02/23   accepted 2005/05/20

Keywords: senescence-accelerated mouse (SAM), SAM prone 8 (SAMP8), leptin, aging, STAT3


We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14—18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.

Copyright © 2005 The Pharmaceutical Society of Japan
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