Effects of 1-Benzylxanthines on Cyclic AMP Phosphodiesterase 4 Isoenzyme

Hirokazu Suzuki; Hiroyuki Sawanishi; Masaaki Nomura; Tsutomu Shimada; Ken-ichi Miyamoto

doi:10.1248/bpb.29.131

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Effects of 1-Benzylxanthines on Cyclic AMP Phosphodiesterase 4 Isoenzyme

Hirokazu Suzuki, Hiroyuki Sawanishi, Masaaki Nomura, Tsutomu Shimada, Ken-ichi Miyamoto

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Keywords: phosphodiesterase 4 inhibitor, 1-benzylxanthine, alkylxanthine

JOURNAL FREE ACCESS

2006 Volume 29 Issue 1 Pages 131-134

DOI https://doi.org/10.1248/bpb.29.131

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Abstract

Based on our results regarding the structure–activity relationships of alkylxanthines and imidazo[2,1-i]purines as phosphodiesterase 4 (PDE4) inhibitors, we designed new 1-benzylxanthines and investigated their PDE4 inhibitory activities. 3,7-Dihydro-7-acetonyl-1-(2,4-dichlorobenzyl)-3-propyl-1H-purine-2,4-dione (2h) exhibited both more selective and more potent PDE4 inhibitory activity than rolipram and XT-611.

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