Synthesis and Biological Evaluation of Novel Benzimidazol/Benzoxazolylethoxypiperidone Oximes

Srinivasan Balasubramanian; Gopalakrishnan Aridoss; Paramasivam Parthiban; Chennan Ramalingan; Senthamaraikannan Kabilan

doi:10.1248/bpb.29.125

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Synthesis and Biological Evaluation of Novel Benzimidazol/Benzoxazolylethoxypiperidone Oximes

Srinivasan Balasubramanian, Gopalakrishnan Aridoss, Paramasivam Parthiban, Chennan Ramalingan, Senthamaraikannan Kabilan

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Keywords: piperidin-4-one, cyanoethylation, benzazole, oxime, antibacterial activity, antifungal activity

JOURNAL FREE ACCESS

2006 Volume 29 Issue 1 Pages 125-130

DOI https://doi.org/10.1248/bpb.29.125

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Abstract

Some novel benzimidazol/benzoxazolylethoxypiperidone oximes were synthesized and their antibacterial activity against Staphylococcus aureus (NCIM-2492), Bacillus subtilis (NCIM-2439), Escherichia coli (NCIM-2345) and Pseudomonas aeruginosa (NCIM-2035) and antifungal activity against Candida albicans (NCIM-C27), Candida-6 (NCIM-C27), Candida-51 (NCIM-C27), Aspergillus niger (NCIM-590) and Aspergillus flavus (NCIM-539) have been evaluated. Compounds 26 and 27 exerted potent in vitro antibacterial activity against Bacillus subtilis, Escherichia coli and Staphylococcus aureus while compounds 26, 29 and 30 exhibited potent in vitro antifungal activity against Candida albicans, Candida-51, and Aspergillus niger.

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