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Biological and Pharmaceutical Bulletin
Vol. 29 (2006) No. 2 P 220-224

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http://doi.org/10.1248/bpb.29.220

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Andrographolide has been reported to possess a variety of pharmacological activities. In this study, we have investigated the effect of andrographolide on the production of TNF-α and IL-12 (Interleukin-12) in murine peritoneal macrophages. Andrographolide decreased TNF-α, IL-12a and IL-12b at mRNA level, and reduced the production of TNF-α and IL-12p70 proteins in a concentration-dependent manner. Furthermore, we have found that addition of andrographolide inhibited the activation of ERK1/2 MAP kinase, but not that of JNK, p38 or NF-κB. These results suggested that andrographolide inhibit LPS-induced production of TNF-α via suppression of the ERK1/2 signaling pathway.

Copyright © 2006 The Pharmaceutical Society of Japan

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