Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation
Hyun LimKun Ho SonHyeun Wook ChangSam Sik KangHyun Pyo Kim
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2006 Volume 29 Issue 5 Pages 1046-1049


Ginkgetin, a biflavonoid from Ginkgo biloba leaves (Ginkgoaceae), was previously demonstrated to inhibit phospholipase A2 and to suppress proinflammatory gene expression such as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase. In this study, the effects of ginkgetin were examined on an animal model of chronic skin inflammation and proinflammatory gene expression. When topically applied to ICR mouse ear, ginkgetin (20—80 μg/ear/treatment) inhibited ear edema (22.8—30.5%) and prostaglandin E2 production (30.2—31.1%) induced by multiple treatment of 12-O-tetradecanoylphorbol-13-acetate (TPA) for 7 consecutive days. By histological comparison, ginkgetin was also found to reduce epidermal hyperplasia. The expression of proinflammatory gene, interleukin-1β, was suppressed by ginkgetin. From the results, it is suggested that ginkgetin may be beneficial against chronic skin inflammatory disorders like atopic dermatitis.

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© 2006 The Pharmaceutical Society of Japan
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