Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Inhibition of Putrescine Aminopropyltransferase Influences Rat Liver Regeneration
Masaki KobayashiKoichi TakaoYasuo ShiotaYoshiaki SugitaMasakazu TakahashiDai NakaeKeijiro Samejima
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2006 Volume 29 Issue 5 Pages 863-867

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Abstract

A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd : spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with MCHA, as a percentage index of remnant liver weight to body weight, correlated well with a decrease of the spd : spm value, with a correlation coefficient of 0.952 for the remnant livers on day 3 after partial hepatectomy. The decrease in recovery rate could be explained by a prolonged cell cycle based on the data of the proliferating cell nuclear antigen labelling index and mitotic cell index in both livers of day 2 and day 3 after partial hepatectomy. The results presented here will give a new aspect in the field of polyamine regulation to control cell growth in vivo.

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© 2006 The Pharmaceutical Society of Japan
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