Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells

Ibrahim Iliya; Yukihiro Akao; Kenji Matsumoto; Yoshihito Nakagawa; Ali Zulfiqar; Tetsuro Ito; Masayoshi Oyama; Hiroko Murata; Toshiyuki Tanaka; Yoshinori Nozawa; Munekazu Iinuma

doi:10.1248/bpb.29.1490

Notes

Growth Inhibition of Stilbenoids in Welwitschiaceae and Gnetaceae through Induction of Apoptosis in Human Leukemia HL60 Cells

Ibrahim Iliya, Yukihiro Akao, Kenji Matsumoto, Yoshihito Nakagawa, Ali Zulfiqar, Tetsuro Ito, Masayoshi Oyama, Hiroko Murata, Toshiyuki Tanaka, Yoshinori Nozawa, Munekazu Iinuma

著者情報

キーワード: gnemonol G, gnetin I, stilbenoid, Welwitschiaceae, Gnetaceae, apoptosis

ジャーナルフリー

2006 年 29 巻 7 号 p. 1490-1492

DOI https://doi.org/10.1248/bpb.29.1490

詳細

抄録

Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC₅₀ of 10.0 μM and 12.2 μM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.

責任著者(Corresponding author)

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