Caffeic Acid Protects Hydrogen Peroxide Induced Cell Damage in WI-38 Human Lung Fibroblast Cells

Kyoung Ah Kang; Kyoung Hwa Lee; Rui Zhang; Meijing Piao; Sungwook Chae; Kil Nam Kim; You Jin Jeon; Doek Bae Park; Ho Jin You; Jin Sook Kim; Jin Won Hyun

doi:10.1248/bpb.29.1820

Regular Articles

Caffeic Acid Protects Hydrogen Peroxide Induced Cell Damage in WI-38 Human Lung Fibroblast Cells

Kyoung Ah Kang, Kyoung Hwa Lee, Rui Zhang, Meijing Piao, Sungwook Chae, Kil Nam Kim, You Jin Jeon, Doek Bae Park, Ho Jin You, Jin Sook Kim, Jin Won Hyun

Author information

Kyoung Ah Kang
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
Kyoung Hwa Lee
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
Rui Zhang
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
Meijing Piao
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
Sungwook Chae
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University
Kil Nam Kim
Department of Food Science and Technology, Cheju National University
You Jin Jeon
Department of Food Science and Technology, Cheju National University
Doek Bae Park
Department of Histology, College of Medicine, Cheju National University
Ho Jin You
Department of Pharmacology, College of Medicine, Chosun University
Jin Sook Kim
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine
Jin Won Hyun
Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University

Keywords: caffeic acid, oxidative stress, catalase

JOURNAL FREE ACCESS

2006 Volume 29 Issue 9 Pages 1820-1824

DOI https://doi.org/10.1248/bpb.29.1820

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Abstract

Cytoprotective effect of caffeic acid (3,4-dihydroxy cinnamic acid) on human lung fibroblast (WI-38) cells against hydrogen peroxide induced damage was investigated. Caffeic acid was found to scavenge intracellular reactive oxygen species, and 1,1-diphenyl-2-picrylhydrazyl radical, and thus prevented lipid peroxidation. The caffeic acid protected cell damage of WI-38 cells exposed to hydrogen peroxide (H₂O₂), via the activation of extracellular signal regulated kinase protein. Caffeic acid increased the activity of catalase and its protein expression. Hence, from the present study, it is suggestive that caffeic acid protects WI-38 cells against H₂O₂ damage by enhancing the cellular antioxidant activity.

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