Solubilization of Dipropofol, an Antibacterial Agent, Using Saccharide and Ascorbic Acid

Masahiro Ogata; Kentaro Oka; Masako Seki; Midori Hoshi; Hirokatsu Takatsu; Tadahiko Mashino; Shiro Urano; Toyoshige Endo

doi:10.1248/bpb.30.1565

Notes

Solubilization of Dipropofol, an Antibacterial Agent, Using Saccharide and Ascorbic Acid

Masahiro Ogata, Kentaro Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

Author information

Keywords: dipropofol, monosaccharide, ascorbic acid, solubilization

JOURNAL FREE ACCESS

2007 Volume 30 Issue 8 Pages 1565-1568

DOI https://doi.org/10.1248/bpb.30.1565

Details

Abstract

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

Corresponding author

Register with J-STAGE for free!