Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Lavandulyl Flavanones from Sophora flavescens Protect Mouse Hippocampal Cells against Glutamate-Induced Neurotoxicity via the Induction of Heme Oxygenase-1
Gil-Saeng JeongBin LiDong-Sung LeeErisa ByunRen-Bo AnHyun-Ock PaeHun-Taeg ChungKwon-Ha YounYoun-Chul Kim
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2008 Volume 31 Issue 10 Pages 1964-1967

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Abstract

Lavandulyl flavanones of Sophora flavescens roots are anti-malarial, anti-inflammatory, and cytotoxic. Here, we examined whether four lavandulyl flavanones, (2S)-2′-methoxykurarinone (1), sophoraflavanone G (2), leachianone A (3), and (−)-kurarinone (4), isolated from S. flavescens could protect HT22 immortalized hippocampal cells against glutamate-induced oxidative stress. Compounds 1 and 2 induced the expression of heme oxygenase (HO)-1 and increased HO activity dose- and time-dependently. These two compounds also suppressed glutamate-induced reactive oxygen species generation in HT22 cells, whereas compounds 3 and 4 were not protective. These two lavandulyl flavanones (compounds 1, 2) may protect against glutamate-induced neurotoxicity via HO-1 induction.

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© 2008 The Pharmaceutical Society of Japan
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