Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Heme Oxygenase-1 Inducing Constituent of Prunella vulgaris in HepG2 Cells
Gil-Saeng JeongRen-Bo AnHyun-Ock PaeGi-Su OhHun-Taeg ChungYoun-Chul Kim
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2008 Volume 31 Issue 3 Pages 531-533

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Abstract

Inducible heme oxygenase (HO)-1 is known to play a major role in the pathogenesis of several diseases, and it protects cells against oxidant-mediated injury. The bioassay-guided fractionation of the EtOH extract of the flowered fruit-spike of Prunella vulgaris L. (Labiatae) yielded two ursane-type triterpenes, 3β,23-dihydroxyurs-12-en-28-oic acid (23-hydroxyursolic acid) (1) and 3β-hydroxyurs-12-en-28-oic acid (ursolic acid) (2). Western blotting demonstrated that treatment with compound 1 increased the expression of HO-1 in a dose-dependent manner in human liver-derived HepG2 cells. Investigation of structure-related HO-1 inducing activity suggested that the hydroxyl group at the C-23 position in the ursane skeleton is important for this activity.

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© 2008 The Pharmaceutical Society of Japan
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