Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Inhibitory Constituents of Aldose Reductase in the Fruiting Body of Phellinus linteus
Yeon Sil LeeYoung-Hee KangJu-Young JungIl-Jun KangSang-No HanJong-Sang ChungHyun-Kyung ShinSoon Sung Lim
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2008 年 31 巻 4 号 p. 765-768

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In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), and ellagic acid (4). Their structures were elucidated by spectroscopic analyses. Among them, davallialactone (7), hypholomine B (9), and ellagic acid (4) exhibited potent rat lens aldose reductase and human recombinant aldose reductase inhibitory activity with IC50 values of 0.33, 0.82, 0.63 μM and 0.56, 1.28, 1.37 μM, respectively.

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© 2008 The Pharmaceutical Society of Japan
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