Bioactive Constituents from Chinese Natural Medicines. XXXIII.  Inhibitors from the Seeds of Psoralea corylifolia on Production of Nitric Oxide in Lipopolysaccharide-Activated Macrophages

Hisashi Matsuda; Sachie Kiyohara; Sachiko Sugimoto; Shin Ando; Seikou Nakamura; Masayuki Yoshikawa

doi:10.1248/bpb.32.147

Notes

Bioactive Constituents from Chinese Natural Medicines. XXXIII. Inhibitors from the Seeds of Psoralea corylifolia on Production of Nitric Oxide in Lipopolysaccharide-Activated Macrophages

Hisashi Matsuda, Sachie Kiyohara, Sachiko Sugimoto, Shin Ando, Seikou Nakamura, Masayuki Yoshikawa

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Keywords: Psoralea corylifolia, inhibitor, nitric oxide production, macrophage, prenylated flavonoid

JOURNAL FREE ACCESS

2009 Volume 32 Issue 1 Pages 147-149

DOI https://doi.org/10.1248/bpb.32.147

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Abstract

The methanolic extract from the seeds of Psoralea corylifolia was found to inhibit production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. Among the isolated compounds, bavachinin (IC₅₀=26 μM), isobavachalcone (17 μM), neobavaisoflavone (ca. 29 μM), corylifol A (ca. 21 μM), and psoralidin (ca. 23 μM) significantly inhibited the accumulation of nitrite (NO₂⁻) as a marker of production of NO. Bakuchiol, which is mainly contained in the extract, also showed weak activity at 10 μM, but cytotoxic effects were observed more than 30 μM.

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