Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Low Dose Estrogen Supplementation Reduces Mortality of Mice in Estrogen-Dependent Human Tumor Xenograft Model
Jong Soon KangMoo Rim KangSang-Bae HanWon Kee YoonJang Hyun KimTaek Chang LeeChang Woo LeeKi Hoon LeeKiho LeeSong-Kyu ParkHwan Mook Kim
著者情報
ジャーナル フリー

2009 年 32 巻 1 号 p. 150-152

詳細
抄録
Breast cancer is one of the most frequent female cancers in the Western world. Perturbation of estrogen levels by hormone replacement therapy or pregnancy is associated with a variety of diseases, including breast cancer. Estrogen supplementation is required to establish appropriate animal models for estrogen-related diseases. In this report, we demonstrated that supplementation with high doses of 17β-estradiol results in deaths in estrogen-dependent MCF-7 tumor xenograft model. Renal damage and bladder stone formation was implicated as a major cause of death. The mortality rate was significantly reduced when mice received a low dose of 17β-estradiol. We also confirmed that low dose of 17β-estradiol supplementation can support the growth of tumors in MCF-7 tumor xenograft model. These results suggest that low dose estrogen supplementation may be more appropriate in estrogen-dependent tumor xenograft models.
著者関連情報
© 2009 The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top