Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients

Yuika Naito; Masakazu Ishii; Ayumu Nagamine; Atsuko Imagawa; Kenji Shida; Johji Takahashi; Yukiko Hosaka; Yuko Naito; Hideto Oyamada; Shunichi Shimizu; Katsuji Oguchi; Hajime Hara; Yutaka Masuda; Shino Usami; Yuji Kiuchi

doi:10.1248/bpb.33.1751

Note

Association of the A-1438G Polymorphism in Serotonin 2A Receptor in Migraine with Aura among Japanese Patients

Yuika Naito, Masakazu Ishii, Ayumu Nagamine, Atsuko Imagawa, Kenji Shida, Johji Takahashi, Yukiko Hosaka, Yuko Naito, Hideto Oyamada, Shunichi Shimizu, Katsuji Oguchi, Hajime Hara, Yutaka Masuda, Shino Usami, Yuji Kiuchi

Author information

Yuika Naito
Department of Pathophysiology, School of Pharmacy, Showa University
Masakazu Ishii
Department of Pathophysiology, School of Pharmacy, Showa University
Ayumu Nagamine
Department of Pathophysiology, School of Pharmacy, Showa University
Atsuko Imagawa
Department of Neurology, Showa University Fujigaoka Hospital
Kenji Shida
Department of Anesthesiology, School of Medicine, Showa University
Johji Takahashi
Department of Neurology, Showa University Fujigaoka Hospital
Yukiko Hosaka
Department of Pathophysiology, School of Pharmacy, Showa University
Yuko Naito
Department of Pathophysiology, School of Pharmacy, Showa University
Hideto Oyamada
Department of Pharmacology, School of Medicine, Showa University
Shunichi Shimizu
Department of Pathophysiology, School of Pharmacy, Showa University
Katsuji Oguchi
Department of Pharmacology, School of Medicine, Showa University
Hajime Hara
Department of Neurology, Showa University Fujigaoka Hospital
Yutaka Masuda
Department of Anesthesiology, School of Medicine, Showa University
Department of Research and Development for Innovative Medical Needs, School of Pharmacy, Showa University
Shino Usami
Department of Pathophysiology, School of Pharmacy, Showa University
Department of Pharmacology, School of Medicine, Showa University
Usami Neurosurgery Clinic/Institute
Yuji Kiuchi
Center of Pharmaceutical Education, School of Pharmacy, Showa University

Keywords: migraine, aura, A-1438G polymorphism, serotonin 2A receptor

JOURNAL FREE ACCESS

2010 Volume 33 Issue 10 Pages 1751-1753

DOI https://doi.org/10.1248/bpb.33.1751

Details

Abstract

We investigated the possible association of serotonin (5-HT) 2A receptor gene A-1438G polymorphism in Japanese patients with migraine. Genotyping of 5-HT_2A A-1438G polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism in patients with migraine (male 17 : 3 with aura and 14 without aura, female 65 : 17 with aura and 48 without aura) and controls (male 31, female 84). The distribution of 5-HT_2A A-1438G genotype frequency between migraine patients and controls did not differ. These results suggest that the A-1438G polymorphism of the 5-HT_2A receptor gene is not a direct risk factor for migraine; however, the incidence of the A/A genotype between migraine with aura (MA) and without aura (MO) was significantly different. The 5-HT_2A A-1438G polymorphism may be involved in determining the subtypes of migraine in Japanese.

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