Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs
Pei YuLongfei XiaJing ZhaoGaoxiao ZhangZaijun ZhangMing LangYuqiang Wang
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2012 Volume 35 Issue 8 Pages 1295-1299

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Abstract

We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.

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© 2012 The Pharmaceutical Society of Japan
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