Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs

Pei Yu; Longfei Xia; Jing Zhao; Gaoxiao Zhang; Zaijun Zhang; Ming Lang; Yuqiang Wang

doi:10.1248/bpb.b12-00145

Regular Articles

Synthesis and Preliminary Anticancer Evaluation of 10-Hydroxycamptothecin Analogs

Pei Yu, Longfei Xia, Jing Zhao, Gaoxiao Zhang, Zaijun Zhang, Ming Lang, Yuqiang Wang

Author information

Pei Yu
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy
Longfei Xia
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy
Jing Zhao
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy
Gaoxiao Zhang
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy
Zaijun Zhang
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy
Ming Lang
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy
Yuqiang Wang
Institute of New Drug Research and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine, Jinan University College of Pharmacy

Keywords: anticancer, 10-hydroxycamptothecin, analog

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Supplementary material

2012 Volume 35 Issue 8 Pages 1295-1299

DOI https://doi.org/10.1248/bpb.b12-00145

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Abstract

We have synthesized new 10-hydroxycamptothecin (HCPT) analogs and evaluated their anticancer activity in cell culture and in experimental animal tumor model. Although the new analogs were less potent against L1210 leukemia cells in vitro, some of them were more efficacious against L1210 leukemia in vivo compared to the parent HCPT.

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