Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Fecal Lipid Excretion after Consumption of a Black Tea Polyphenol Containing Beverage–Randomized, Placebo-Controlled, Double-Blind, Crossover Study–
Hiroshi AshigaiYoshimasa TaniguchiMihoko SuzukiEmiko IkeshimaTomoka KanayaKanako ZembutsuShimpei TomitaMika MiyakeIkuo Fukuhara
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2016 Volume 39 Issue 5 Pages 699-704

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Abstract

Obesity is a serious medical condition worldwide. Inhibition of lipid absorption is very important in preventing obesity. In a previous study, we found that postprandial elevation of triacylglycerol was suppressed by the intake of black tea polyphenol (BTP). We also reported that BTP caused lipid excretion into feces in an animal study. The present study is a clinical trial that examined lipid excretion. In this randomized, placebo-controlled, double-blind, crossover study, in the first test period participants were asked to drink either a beverage containing 55 mg BTP or a control beverage without BTP 3 times a day for 10 d. After an 11-d interval, for the second test period, they then drank the alternate test beverage 3 times a day for 10 d. During the test periods, the participants were asked to eat meals standardized according to calorie and fat content. Stool samples were obtained during the last 3 d of each test period for fecal lipid measurements. Total lipid excretion increased from 5.51±1.73 to 6.87±1.91 g/3 d after BTP intake in comparison with intake of the control beverage. These results indicated that BTP increased lipid excretion.

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© 2016 The Pharmaceutical Society of Japan
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