Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Regular Articles
Dietary Nitrite Attenuates Elastase-Induced Pulmonary Emphysema in a Mouse Model
Kunihiro SonodaKazuo OhtakeMaya TagiriMiku HirataHazuki TamadaHiroyuki UchidaJunta ItoJun Kobayashi
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2018 Volume 41 Issue 12 Pages 1818-1823

Details
Abstract

Pulmonary emphysema (PE) is a major pathological feature of chronic obstructive pulmonary disease (COPD) and is characterized by proteolytic destruction of the alveolar structure and subsequent inflammation of the respiratory tract. We hypothesized that nitrite attenuates the development of PE via anti-inflammatory actions. PE was induced by intratracheal instillation of porcine pancreas elastase (PPE) in mice. Dietary nitrite dose-dependently (50 and 150 mg/L in drinking water) attenuated emphysematous development and macrophage accumulation in the alveolar parenchyma 21 d after PPE treatment. The present study shows that dietary nitrite might be a possible nutritional strategy in preventing the development of PE in mice.

Graphical Abstract Fullsize Image
Information related to the author
© 2018 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top