Ursolic Acid Inhibits Tumor Growth via Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells

Xianmin Wang; Ting Wang; Fan Yi; Chunyan Duan; Qiaoling Wanwg; Nana He; Lei Zhu; Qi Li; Wanli Deng

doi:10.1248/bpb.b18-00613

Regular Articles

Ursolic Acid Inhibits Tumor Growth via Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells

Xianmin Wang, Ting Wang, Fan Yi, Chunyan Duan, Qiaoling Wanwg, Nana He, Lei Zhu, Qi Li, Wanli Deng

Author information

Xianmin Wang
Department of Traditional Chinese Medicine of Traditional Chinese Medical Hospital affiliated Xinjiang Medical University
Ting Wang
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Fan Yi
Department of Digestive Diseases, Urumqi Hospital of Traditional Chinese Medicine
Chunyan Duan
Oncology Department I of Traditional Chinese Medical Hospital affiliated Xinjiang Medical University
Qiaoling Wanwg
Oncology Department I of Traditional Chinese Medical Hospital affiliated Xinjiang Medical University
Nana He
Oncology Department I of Traditional Chinese Medical Hospital affiliated Xinjiang Medical University
Lei Zhu
Department of Internal Medicine IV, Changji Traditional Chinese Medicine Hospital of Xinjiang
Qi Li
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Wanli Deng Corresponding author
Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine
Oncology Department I of Traditional Chinese Medical Hospital affiliated Xinjiang Medical University

Keywords: colorectal cancer, epithelial–mesenchymal transition, metastasis, ursolic acid, invasion, metastasis

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2019 Volume 42 Issue 5 Pages 685-691

DOI https://doi.org/10.1248/bpb.b18-00613

J-STAGE : bpb 43 1 pp.194-194

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Abstract

Ursolic acid (UA), a natural pentacyclic triterpenoid, is a promising compound for cancer prevention and therapy. However, its mechanisms of action have not been well elucidated in colorectal cancer cells. Here, using cultured human colon cancer cell lines SW620 and HCT116, this assay demonstrates that UA reduces cell viability, inhibits cell clone formation, and induces caspase-3 mediated apoptosis. Additional experiments show that UA inhibits cell migration and epithelial-mesenchymal transition (EMT), including E-cadherin, Vimentin, Integrin, Twist, and Zeb1 biomakers. These results suggest that UA inhibits cell proliferation, invasion, and metastasis in colorectal cancer cells by affecting mechanisms that regulate EMT. Taken together, the results suggested that the anti-proliferation and anti-metastasis activities of UA was through EMT inhibition in colorectal cancer.

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