Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Inhibition Mechanisms of Hepatitis C Virus Infection by Caffeic Acid and Tannic Acid
Yoshitaka ShirasagoYoko InamoriTakeru SuzukiIsei TanidaTetsuro SuzukiKazuo SugiyamaTakaji WakitaKentaro HanadaMasayoshi Fukasawa
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2019 Volume 42 Issue 5 Pages 770-777

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Abstract

Previously, we reported that coffee extract and its constituents, caffeic acid (CA) and p-coumaric acid, inhibit infection by the hepatitis C virus (HCV). In the present report, we identified another coffee-related compound, tannic acid (TA), which also inhibits HCV infection. We systematically evaluated which steps of the viral lifecycle were affected by CA and TA. TA substantially inhibits HCV RNA replication and egression, while CA does not. The infectivity of the HCV pretreated with CA or TA was almost lost. Cellular attachment of HCV particles and their interaction with apolipoprotein E, which is essential for HCV infectivity, were significantly reduced by CA. These results indicate that CA inhibits HCV entry via its direct effect on viral particles and TA inhibits HCV RNA replication and particle egression as well as entry into host cells. Taken together, our findings may provide insights into CA and TA as potential anti-HCV strategies.

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© 2019 The Pharmaceutical Society of Japan
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