1989 年 12 巻 8 号 p. 468-475
The relationships between contraceptive activity, hydrophobic character and alkaline hydrolysis rates were studied in three homologous series of norethisterone and levonorgestrel esters. Hydrophobic character was expressed by the high-performance liquid chromatographic retention term, VR (w) or retention volume at 100% aqueous mobile phase. A parabolic and bilinear relationship was shown between log VR (w) and log biological response. No correlation between second-order alkaline hydrolysis rates, K2, measured in 70% (v/v) aqueous dioxan and contraceptive activity was established.