ENHANCEMENT OF LYMPHATIC TRANSPORT OF 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL BY WATER-IN-OIL EMULSION

YASUO NAKAMOTO; TOSHIYUKI TAKEEDA; FUMIYO SAKIKAWA; KAZUHIRO MORIMOTO; KATSUAKI MORISAKA; SHOZO MURANISHI; HITOSHI SEZAKI

doi:10.1248/bpb1978.2.45

YASUO NAKAMOTO, TOSHIYUKI TAKEEDA, FUMIYO SAKIKAWA, KAZUHIRO MORIMOTO, KATSUAKI MORISAKA, SHOZO MURANISHI, HITOSHI SEZAKI

著者情報

キーワード: electron micrograph

ジャーナルフリー

1979 年 2 巻 1 号 p. 45-51

DOI https://doi.org/10.1248/bpb1978.2.45

詳細

抄録

Enhancement of the lymphatic transport of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207), an orally active anticancer agent, was demonstrated by the administration of W/O emulsion into the loop of rat small intestine. The lymphatic transport of FT-207 was inhibited by the presence of bile. Absorption of oil in the absence of bile was confirmed by light microscopy. Electron micrograph revealed that oil droplets are mainly transported via the lymphatic system.

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