Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
HYPOTENSIVE EFFECT OF CAPTOPRIL IN RELATION TO PLASMA RENIN ACTIVITY IN ANESTHETIZED RATS
SUSUMU SATOHMIZUE SUZUKIHIROKO SATOH
著者情報
キーワード: anesthetized rat
ジャーナル フリー

1980 年 3 巻 5 号 p. 258-260

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抄録
The effect of captopril (D-3-mercapto-2-methylpropanoyl-L-proline), a converting enzyme inhibitor, on the systemic blood pressure in pentobarbital anesthetized rats was investigated. Experiments were performed in four groups of rats : untreated, Na-restricted, furosemide treated and bilaterally nephrectomized, respectively. Intravenous injection of 1 mg/kg of captopril caused a significant hypotensive effect in the three groups of rats but not in the nephrectomized group. Individual values for the hypotensive effect produced by captopril and plasma renin activity obtained just before injection of captopril showed a highly significant correlation.
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© The Pharmaceutical Society of Japan
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