A PHARMCOKINETIC MODEL FOR ENTEROHEPATIC CIRCULATION OF AN ANALGESIC l-1, 4-DIMETHYL-10-HYDROXY-2, 3, 4, 5, 6, 7-HEXAHYDRO-1, 6-METHANO-1H-4-BENZAZONINE HYDROBROMIDE (l-ST-2121) IN RATS

TAMOTSU KOIZUMI; MASAWO KAKEMI; KAZUNORI KATAYAMA; MICHITAKA OGAWA

doi:10.1248/bpb1978.4.461

TAMOTSU KOIZUMI, MASAWO KAKEMI, KAZUNORI KATAYAMA, MICHITAKA OGAWA

著者情報

キーワード: l-1, 4-dimethyl-10-hydroxy-2, 3, 4, 5, 6, 7-hexahydro-1, 6-methano-1 H-4-benzazonine hydrobromide (l-ST-2121)

ジャーナルフリー

1981 年 4 巻 7 号 p. 461-468

DOI https://doi.org/10.1248/bpb1978.4.461

詳細

抄録

Simple compartment models are presented to describe various aspects of enterohepatic circulation pharmacokinetics of an analgesic (l-ST-2121) in rats reported previously. Appearance of trigonometric functions in the analytically integrated blood level equation adequately describes the periodic nature of the process.

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