抄録
The effects of angiotensins on the motility of highly washed human sperm were examined by multiple exposure photography system. The addition of low doses (0.1-10 ng/ml) of angiotensin II (AT II) stimulated the forward velocity of sperm without increasing the percentage of motility. On the contrary, high concentration (1.0 μg/ml) of AT II suppressed the motility. The direct effect of angiotensin I (AT I) on the motility was observed under the presence of SQ 14225, a specific inhibitor of angiotensin I converting enzyme (ACE). AT I (0.1-100 ng/ml) gave no influence on the motility, whereas that of high dose (1.0 μg/ml) suppressed the motility in the same manner as the corresponding dose of AT II. The action of AT II on the motility was completely suppressed under the coexistense of saralasin, a specific antagonist anainst AT II. This fact indicated that the action of AT II on the sperm appeared through the specific receptor on sperm.
