ABSORPTION OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR (rhG-CSP) AND BLOOD LEUKOCYTE DYNAMICS FOLLOWING INTRANASAL ADMINISTRATION IN RABBITS

Yoshiteru WATANABE; Yoshiaki MATSUMOTO; Miho YAMAGUCHI; Rie KIKUCHI; Kazuo TAKAYAMA; Hideaki NOMURA; Kazutoshi MARUYAMA; Mitsuo MATSUMOTO

doi:10.1248/bpb.16.93

Yoshiteru WATANABE, Yoshiaki MATSUMOTO, Miho YAMAGUCHI, Rie KIKUCHI, Kazuo TAKAYAMA, Hideaki NOMURA, Kazutoshi MARUYAMA, Mitsuo MATSUMOTO

Author information

Keywords: granulocyte colony-stimulating factor, nasal absorption, dimethyl-β-cyclodextrin, serum rhG-CSF level, blood total leukocyte number

JOURNAL FREE ACCESS

1993 Volume 16 Issue 1 Pages 93-95

DOI https://doi.org/10.1248/bpb.16.93

Details

Abstract

Absorption of recombinant human granulocyte colony-stimulating factors (rhG-CSF) following intranasal administration of aqueous preparations containing rhG-CSF with or without dimethyl-β-cyclodextrin was investigated. It was found that rhG-CSF was absorbed and the total leukocyte numbers in peripheral blood markedly increased after intranasal instillation of rhG-CSF solution (pH 4) without excipients. Simultaneously administered dimethyl-β-cyclodextrin enhanced nasal absorption of rhG-CSF. Consequently, serum rhG-CSF concentrations and total leukocyte numbers were greatly increased.

Corresponding author

Register with J-STAGE for free!