Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Rat Selection Test with Respect to Laxative Activity Induced by Barbaloin
Yasuko ISHIIHisayuki TANIZAWAYoshio TAKINO
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1993 Volume 16 Issue 10 Pages 1040

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Abstract

As individual differences in sensitivity in the laxative activity of barbaloin were observed in rats, a selection test for barbaloin (31.1 mg/kg, p.o.) was carried out between 1989 and 1991. The annual percentages of rats exhibiting a reaction positive to barbaloin were almost constant (about 57%). We propose that rats positive to barbaloin should be selected for studies on the laxative effect of barbaloin.

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© The Pharmaceutical Society of Japan
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